A recent paper was published on the use of capillary electrophoresis to select DNA aptamers for lysozyme by Tran et al in Molecules: http://www.mdpi.com/1420-3049/15/3/1127/ This is nothing new as capillary electrophoresis has been used for a number of years to select aptamers, first published by Krylov's lab in Canada. For a review of the methods and current papers, check out pubmed, wikipedia, and this figure from Andrei Drabovich:

The selection method sounds very appealing for a number of reasons:


The selection method sounds very appealing for a number of reasons:
- Fast selection since fewer rounds are required - 3-5 vs 8-12
- Little protein necessary - 0.1pmol or less compared to 200pmol/round
- Binding assays can be performed with the CE
- Collection times/volumes
- Buffer incompatibility - rumors you can't use divalent ions because of sticking to the tube walls
- Experience required to use the machine effectively
- The pool or primer set must be ordered with fluorescence for detection on the CE

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