have you considered this target?

USP14 "a deubiquitinating enzyme (DUB) that interferes with the breakdown of misfolded proteins. Since misfolded protein accumulation is thought to play a role in neurodegenerative diseases, control over their degradation could lead to future therapeutics for conditions such as Alzheimer’s disease" (BioTechniques article, link below). If we inhibited this enzyme with an aptamer, then goodbye protein accumulation (or something like that) & cure for disease ...


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