Fibroblast Growth Factor 8 (FGF-8) is a member of the growth factor family that plays pivotal roles in a number of developmental processes. FGF-8’s many functions can be attributed to alternative splicing, which generates eight different isoforms in mice(1). One isoform that has become a focus of many studies is Fibroblast Growth Factor 8b (FGF-8b). This isoform is most active during embryogenesis when it helps organize and induce development. For example, FGF-8b is extremely important in early neural development and differentiation of cells (2). Moreover, it has been shown to function in the isthmus where its activation of the Ras-ERK signaling pathway induces midbrain-hindbrain differentiation and the development of the cerebellum (3).
Progress Report 1
Progress Report 2