tag:blogger.com,1999:blog-1195222727010537305.post2781434922204825321..comments2023-08-03T07:13:32.291-05:00Comments on Aptamer Project Site - 10% APS for Everyone: Nucleic Acid Aptamer Selection against TfR for the Therapeutic Treatment of Lysosomal Storage DiseasesAptamer Staffhttp://www.blogger.com/profile/11584531632318072295noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-1195222727010537305.post-34549885478551443262010-09-13T16:30:30.441-05:002010-09-13T16:30:30.441-05:00Make sure you keep your citations, font and genera...Make sure you keep your citations, font and general format constant throughout your reports.<br /><br />Although you want to narrow down your information you don't want it to be too general when discussing the importance of your target especially when it is related to a particular pathway of an illness.Nia_Fernandezhttps://www.blogger.com/profile/06524075862801694775noreply@blogger.comtag:blogger.com,1999:blog-1195222727010537305.post-45393364591939641542010-09-09T11:49:20.514-05:002010-09-09T11:49:20.514-05:00Bonnie,
Since Chen has already selected an aptame...Bonnie,<br /><br />Since Chen has already selected an aptamer for this purpose, you should describe his findings in more detail (1-2 sentences). How will yours be different (as Gwen suggested)? Are there other receptors that would work equally as well? It is certainly a good project and you have past experiments to backup the utility of these ideas, but you may consider how your aptamer would differ against TfR or if there are other receptors you could go after.Brad Hallhttps://www.blogger.com/profile/10516353314281930175noreply@blogger.comtag:blogger.com,1999:blog-1195222727010537305.post-74298830378453418842010-09-08T11:46:19.983-05:002010-09-08T11:46:19.983-05:00Hey Bonnie, great start to the paper. I was just c...Hey Bonnie, great start to the paper. I was just curious if there are benefits of functionalizing the aptamer after selection, instead of doing it before. Would it not be easier to select an aptamer from a pool already synthesized with the lysosomal enzyme? Does functionalizing afterward affect the conformation of TfR?Alec Rezighhttps://www.blogger.com/profile/01860358482033227957noreply@blogger.comtag:blogger.com,1999:blog-1195222727010537305.post-52144026208996639922010-09-08T11:27:24.624-05:002010-09-08T11:27:24.624-05:00Good start.
Try to avoid vague statements, like &...Good start.<br /><br />Try to avoid vague statements, like "can lead to many harmful effects on cells..." Instead, tell us specifically about the harmful effects. <br /><br />Consider mentioning the number of people afflicted with such diseases or further describing the symptoms. <br /><br />How will your selection differ from Chen's selection?Gwen Stovallhttps://www.blogger.com/profile/11462038982643107356noreply@blogger.com